Direct visualization of ion-channel gating in a native environment
نویسندگان
چکیده
منابع مشابه
Capturing Ion Channel Gating
This is a golden age for ion channels: a time when chemistry, molecular biology, and electrophysiology have come together with structural biology to provide glimpses into some truly amazing membrane proteins. And yet, as usual, the answers yield more questions. Is a new structure the structure of an open channel or of a closed one? How does the voltage sensor actually move? Though providing ama...
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An anomalous diffusion model for ion channel gating is put forward. This scheme is able to describe nonexponential, power-law-like distributions of residence time intervals in several types of ion channels. Our method presents a generalization of the discrete diffusion model by Millhauser, Salpeter, and Oswald [Proc. Natl. Acad. Sci. U.S.A. 85, 1503 (1988)] to the case of a continuous, anomalou...
متن کاملStochastic models of ion channel gating
Stochastic models of ion channel gating date back as far as the pioneering work of Hodgkin and Huxley (1952), whose gating variables are often interpreted as probabilities. Sakmann and Neher directed the efforts that led to the first single-channel recordings, for which they won the Nobel Prize in Physiology and Medicine in 1991. Single-channel recordings (Sakmann and Neher, 1995) demonstrate t...
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Three-dimensional images of the open state of the nicotinic acetylcholine receptor have been obtained at 9 A resolution. Comparison with the closed state reveals the structural basis of channel gating.
متن کاملCalcium ion as a cofactor in Na channel gating.
Calcium ions in the external medium stabilize the resting state of voltage-dependent channels, including Na channels. This effect of calcium on channel gating is usually explained in terms of the surface charge hypothesis, which proposes that local adsorption of calcium ion to the outside of the membrane alters the intramembranous electric field, thus influencing channel behavior indirectly. Ca...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2018
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1814277115